The shortage of donor organs is a serious problem for thousands of patients standing in line for a transplant. To solve the problem came from Chinese scientists who have edited the genome of pigs, providing a record level of compatibility of their tissues with the human body. The experiment was successful, and soon plans to begin clinical trials on patients.
The Chinese company Qihan Bio used the CRISPR technique, also called “genetic scissors” for growing pigs with the tissue possessing all the necessary properties for a successful transplant people. Genetic modification has been made to “clean” animal DNA from traces of viruses that cause rejection of the transplant tissue person. To prevent this process, the researchers edited the 13 genes is allowed to suppress the immune response of the human body for the transplant and to regulate the level of blood clotting.
After a series of complicated manipulations with DNA were established with embryos of new genes, transplanted “surrogate mothers.” Cells of piglets born was subjected to another modification – the result will be a generation of swine, tissue which can “bypass” the protection of the human immune system and effectively take root. In 2020, the company intends to focus on more research, and beginning clinical trials with transplantation of swine organs to humans is planned to begin within the next five years.