Harvard scientists have discovered a gene leading to the development of amyotrophic lateral sclerosis suffered renowned astrophysicist Stephen Hawking. It is reported by Nature Neuroscience.
It turned out that the excessive activity of the gene C9orf72 leads to the development of fatal disease of the Central nervous system. It leads to paralysis of the limbs and muscle atrophy. Known treatment can only delay the course of the disease.
Gene is in the DNA that is responsible for the Assembly of proteins involved in transmitting signals between nerve cells. When the C9orf72 gene becomes more active it creates its “clones” that violates the communication with nerve cells.
Experts suddenly discovered the same “pathology” in yeast cells. Research on flies fruit flies has shown that reducing the activity of the genome of RPS25 that encodes the C9orf72 gene, significantly prolongs their life.
It is unknown what will delete all copies of RPS25 in humans, and how the study of yeast will help in treatment of deadly disease.