Researchers from Exeter University (UK) found a group of genes that play a major role in the aging process.
These genes are able to regulate the splicing factors – molecules that define the path of maturation of RNA, says MedicalXpress.
An important role in coding protein plays spliceosome – complexes with RNA and proteins. The factors that determine the activity of spliceosome are regulated by transcription factors – other proteins that bind DNA and can activate or “turn off” certain genes.
Stop the activity of the ERK and AKT pathways, which transmit signals from outside cells to the genes, reduced the number of cells that are aging in cultures that grew in the lab. To stop activity paths in the study used inhibitors, which are already used as anticancer drug in clinic.
When the scientists destroyed the way of ERK and AKT, they recorded an increase of splicing factors. This means more effective interaction between proteins and genes.
They noticed a decrease in the number of cells that are aging. The researchers also recorded the change many features of these cells. In the result, this has led to the rejuvenation of the cells.
Scientists have figured out how to stop the aging process of the cells in the body
Scientists are convinced that the results of the study will help to establish methods of dealing with aging and chronic diseases and cancer.
What is splicing? It is the process of cutting its introns are (piece of DNA) from the RNA molecules and stitching together the exons (the portion of DNA which is in contrast to the exons contain information about the sequence of amino acids of the protein). The result is the maturation of the molecule.
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