Scientists from the University of Manchester in the UK has identified weaknesses in the virus SARS-CoV-2, which act as targets for antibodies and is able to activate the immune response. Article scientists published in the journal Annals of the Rheumatic Diseases.
The study involved 20 patients with dermatomyositis – severe autoimmune disease that affects connective and muscular tissue. It is known that the risk of the disease, which also involved the immune system, influenced by genetic factors and environmental factors, including viral and bacterial infection. Experts analyzed what unique or antibodies found in a large number of those who are diagnosed with dermatomyositis.
Scientists are focusing on those antibodies that are aimed at viruses belonging to the family of coronaviruses. It turned out that in patients with dermatomyositis there is a large number of antibodies aimed at ten epitopes (specific sites of proteins) in three species of coronaviruses of bats. Experts have compared the sequence of aminokislot the epitopes with the sequences from SARS-CoV-2 and found three identical epitope including the sequence in the RNA-dependent RNA polymerase responsible for the replication of the virus.
These epitopes may be targets for effective vaccines against SARS-CoV-2. In addition, scientists have suggested that infection with coronaviruses can cause the development of autoimmune disease.