“Not only are the viruses of the common cold like nasal mucosa. To enter the body and spread it, it prefers to use and Sars-Coronavirus-2, was discovered by American scientists from North Carolina. Their findings are published in the scientific journal Cell,” reports the German newspaper Frankfurter Rundschau.
“Initially, many scholars assumed that the first coronavirus infects the tissue of the pharynx and then, in the course of the disease into the lower respiratory tract. It seemed that this assumption is suitable and what at first a runny nose was considered a rather rare symptom in Covid-19 and, in General, after infection the first symptom was often a sore throat”.
But now scientists came to the conclusion that the virus should be the other way. “In their opinion, it first affects the cells of the nasal cavity and thence with body fluids gets into the deep lung. Through the nose Sars-CoV-2 can also get into the brain, which, according to current data, can also be infected with a virus”.
“To study the path of the virus, the researchers have reconstructed in the laboratory on the basis of available genetic data on Sars-CoV-2 artificial double, who glows green under fluorescence. Using a highly sensitive method, they also studied different types of cells in the mucosa of the nose, pharynx and bronchi to set the content of the receptor ACE2. This receptor is critical for Covid-19, because the virus clings to him to get inside the cell. The researchers found that the concentration of the receptor ACE2 was reduced in the direction from the upper respiratory tract to the lower. This means that in the cells of the nasal mucosa were more than in cells of the pharynx and the bronchi”.
In the second part of the study, the researchers found that “antibodies found in the blood of patients after the disease SARS in a laboratory experiment to a small extent, can restrain the multiplication of Sars-CoV-2. This may indicate that people who recover from SARS or MERS, have partial immunity against Sars-CoV-2, which contributes to a milder course of the disease. Scientists also think it is possible that such partial immunity may have people who recover from one of the most common colds caused by coronaviruses”.
“However, these results do not lead to the conclusion that another way – direct infection of the lungs does not occur. However, he now seems “less likely”. Assuming that at first the virus infects the nasal mucosa or the lungs then, it is time you can use to help with therapy to prevent pulmonary infection,” reports the Frankfurter Rundschau.