Researchers from the US conducted a detailed analysis of a large collection of genome of the coronavirus and found that evolution “made of several pieces” – mostly of bats, but there are inserts and pangolin. The results of the report ArsTechnica writes.
Scientists believe that the point of recombination is a natural genetic process in cells when the two DNA molecules, having similarity can exchange parts. According to experts, it happened with the coronavirus that caused the pandemic.
“The coronavirus genome consists of a single long RNA molecule, but it is capable of recombination. The enzyme that copies the genome RNA may fail to create a partial copy of a molecule with other elements, joined. Wherein the second molecule need not be identical, it just needs to be pretty similar. As a result, this process allows to recombine relatively distant from the point of view of evolution of viruses,” the article says.
It is reported that in the course of the study, the researchers assembled a collection of 43 different species of coronavirus taken from different animal species and humans. Basic analysis of the genome confirmed that SARS-CoV-2 closest to the viruses of bats. But different parts of the RNA closer to different viruses these animals, which, according to scientists, corresponds to the result of recombination.
Also, researchers say they have found a zone change which leads to disruption of the essential functions of the virus.
“These zones are a few, but the most sensitive are located in the proteins of the crown, inherited the virus from pangolin. If influence, any drug can be deprived of SARS-CoV-2 ability to infect human cells,” say scientists.