Synthetic enzyme reduced accumulation of proteins in Alzheimer’s disease

Синтетический фермент уменьшил скопления белков при болезни Альцгеймера

Scientists have developed synthetic enzymes that aim at toxic proteins in the brain. They are the cause of senile dementia.

It is well known that the most common form of senile dementia Alzheimer’s disease is called toxic aggregations of proteins. The neurons in our brain produce a protein called beta-amyloid. These proteins in themselves are monomers of beta-amyloid, which perform important tasks for neurons. But in the brain of victims of Alzheimer’s disease the monomers of beta-amyloid do not perform their work, and instead begins to accumulate between them. They form oligomers – small clusters of a dozen proteins, which then expand and turn into plaque.

For many years scientists believed that these protein plaques and cause of intellectual disabilities senile dementia. A new study has shown that small clusters of beta-amyloid are the toxic elements of the disease. It turned out that the synthetic enzymes designed to form a special network structure in the brain, can block the accumulation of beta-amyloid at the earliest and the most toxic stage where only oligomers are formed.

A team of scientists has demonstrated that these enzymes possess blocking activity, reduces beta-amyloid toxicity in human neuronal cells in laboratory cultures. This was later confirmed in animal models. This discovery confirms the hypothesis that beta-amyloid oligomers, rather than plaques or clusters and are the most toxic agents, leading to Alzheimer’s disease.