The older people are, the more they have immunity against adenovirus. Therefore, when you use this worse vaccine produces immunity in the elderly.
Chinese vector vaccine COVID-19 showed a low efficacy in the elderly. Scientists suggest that they may need additional vaccination.
The results of the second phase of the clinical study of recombinant adenovirus vector vaccine COVID-19 published in the prestigious journal the Lancet, says the channel 24.
The study itself was conducted in April, and was attended by over 500 people. The vaccine with the working title Ad5-nCoV developed on the basis of devoid of pathogenicity of adenovirus. Embedded in its genome the gene of the virus SARS-CoV-2. Adenovirus delivers the genes of SARS-CoV-2 in the human body, and the corresponding proteins of the coronavirus in humans antibodies.
The main purpose of the study was to evaluate the immune response to the vaccine and to determine the most appropriate dose to be used in the next phase. Next, the third phase of the study will have to show whether the vaccine protects from COVID-19 in real life.
Side effects of Chinese vaccine
Serious side effects of the vaccine in this study was not registered. The main adverse reactions were pain at the injection site, fever, weakness.
95% of participants who received high dose of vaccine, the scientists found the production of T-cells or antibodies against the coronavirus. In the group with a low dose they were found in 91% of the participants.
The authors of the study indicate that participants who have been immune to adenovirus, which was used for the manufacture of the vaccine, develop immunity to SARS-CoV-2 was much worse. Only 52% of study participants were identified immunity to the adenovirus pre-vaccination.
The older people are, the more they have immunity against adenovirus. Therefore, when you use this worse vaccine produces immunity in the elderly. Suffer the production of antibodies.
The authors indicate that elderly people – the most important group that needs protection from COVID-19. They do not exclude that older people need more vaccination. If this helps, but new research.
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