Exeter University scientists in the UK and the University of Connecticut in the USA have discovered a gene that influences the high risk of infection with coronavirus and severe forms COVID-19. In people with two defective copies of APOE, which also contribute to Alzheimer’s disease, a twofold increase in the risk of life-threatening coronavirus infection with complications. Article researchers published in the Journal of the American Medical Association.
Previously, scientists have found that people with dementia are three times more likely to develop severe COVID-19, however this could be explained by the high prevalence of the virus in nursing homes. However, the results of data analysis about the health and genetics of a few hundred thousand people has shown that the key role played by the APOE e4e4 genotype. 2.36% of participants (about nine thousand people) have the defective genes, but among people with COVID mutations met at 5.13 percent.
It also demonstrates that the increased risk of Alzheimer’s disease that seems inevitable with age, is actually associated with certain biological differences, which some people live to a hundred years and remain active and others become disabled and die in 60 years.