Researchers from Australian Flinders University found that overweight might be a plus in the treatment of non-small cell lung cancer. An article about this published in JAMA Oncology.
Tatlisumak is a drug used in immunotherapy of cancer, including urothelial cancer, different types of lung cancer, breast cancer. The researchers analyzed data obtained during therapy using tatlisumak, and found that the patient’s weight is above average and excess are associated with better response to treatment. This increase in sensitivity to the drug found in people with non-small cell lung cancer.
BMI – the body mass index, i.e. the ratio of the weight-for-height. Values above 25 kg / m2 indicate overweight. In the work of Australian scientists studied the data of 1434 participants. 49% of them had normal weight, 34% were overweight, and 7% diagnosed ojierenem. In four clinical trials for the Australian team found a significant reduction in mortality when using tatlisumak in patients with BMI more than 25 kg / m2. “Although in our research we relied only on the initial data and the data during treatment, we believe that more research is needed the potential protective role of high BMI with other methods of cancer treatment”, – stated in the work.
Scientists note that the previously studied hypothesis of “obesity paradox” in cancer immunotherapy. It suggests that despite the relationship of excess weight with increased risk of illness many types of cancer, in other cases, he can defend, increasing the likelihood of survival. This work provides new evidence supporting this hypothesis. The authors believe that further studies can help to detect a possible Association between BMI and concomitant inflammation. New work will be able to clarify the mechanisms of this paradoxical response to certain types of cancer therapy.
Not less than 2.8 million people, according to who, die each year from diseases associated with overweight and obesity. High BMI is associated with metabolicheskie disorders that affect various indicators of health: blood pressure, cholesterol and triglycerides in the blood, insulin resistance. The risk of coronary heart disease, stroke and type 2 diabetes mellitus type increases significantly when a large weight.